Intercity bus is the way most people come to Antakya(Hatay).
The modern Hatay Otogarı (intercity bus terminal) is 5.5 km (3.4 miles) northwest of the center of Antakya (map).
The city has direct bus service from Ankara and several other cities, and very frequent service from Adana, so if you have any trouble finding a direct bus to Antakya, just take any bus to Adana, then change for a bus to Antakya.
From Antakya, there's frequent service to the Syrian border where you can find other buses going to Aleppo (Halep, Halab), Damascus (Dimashk, Sam) and other points in Syria—though you'll probably want to wait until the Syrian civil war is over....
—by Tom Brosnahan