The first big chase scene takes place in and around the Grand Bazaar, especially the Büyük Valide Han and on the roofs of the bazaar:
Filming in Istanbul was scheduled for April-May 2012.
(On April 19th, southern lodos winds tore through Istanbul at up to 130 km (81 miles) per hour, wrecking the sets and equipment in Eminönü.)
Directed by Sam Mendes, stars include Daniel Craig, Judy Dench, Tonia Sotiropoulou, Naomie Harris, Javier Bardem, Ben Whishaw, Albert Finney and Rory Kinnear, with a screenplay by Neal Purvis, Robert Wadeand John Logan, and musical score by Thomas Newman. Roger Deakins directs the photography.
Skyfall was released first in the United Kingdom and Ireland on October 26th, in Turkey on November 2nd, and in North America on November 9th.
You may want to compare it with those other classic motion pictures filmed in Turkey, From Russia with Love and Topkapi.