Almost all transport to and from Pamukkale is via the nearby city of Denizli which has a large and active bus terminal, train station and airport.
Here's how to travel between Pamukkale
Here's how to go by train from Selçuk (Ephesus) to Denizli and Pamukkale, see the sights, and return by train all in one day. More...
The new (2014) Denizli Metropolitan Bus Terminal (Denizli Büyükşehir Otobüs Terminali),
called the Denizli Otogar, is a grand, well-designed facility in the center of Denizli 18 km (11 miles) south of Pamukkale (map).
There is an Emanetçi (Left Luggage/Baggage Check) on the lower (minibus) level.
Numerous bus companies operate between Denizli and İzmir (every half hour!), Antalya, Konya, Cappadocia (Nevşehir and Kayseri), and Istanbul. You should have no problem finding a good departure to any of those destinations, and indeed many others.
To Selçuk (for Ephesus), there are 3 daily buses that take 4 hours. The train (see below) is preferable: faster, cheaper and more comfortable. Otherwise, you can travel via İzmir to Selçuk, which is longer in both time and distance.
Denizli's grand new bus terminal (Otogar):
impressive, and easy to use...
Denizli Gar (railway
station) a few minutes' walk west from
the Denizli bus terminal on the other side
of the highway, is served by six
good daily trains from İzmir's
Gar via Adnan
Menderes Airport, Selçuk
(Ephesus), Aydın and
Nazilli. Train is the preferred transport method on this route: cheaper than the bus, in similar or faster times, and more comfortable.
Fare between Denizli and Selçuk
(Ephesus) is TL14.50. The journey takes a little over 3 hours. More...
You can ride the train from Ephesus to Pamukkale and back in one day if you do it just right. More...
Formerly an overnight train with sleeping cars, the Pamukkale Ekspresi reconstituted in 2015 is a daytime train between Denizli and Eskişehir via Afyon and Kütahya. At Eskişehir it meets the High-Speed Train to Istanbul. More...
Denizli Çardak Airport (DNZ) is 64 km (40 miles, 1.25 hours) east of Denizli city center, 71 km (44 miles) east of Pamukkale(map), past Bozkurt then south of the D320 highway. More...
Pegasus Airlines and Turkish Airlines have daily one-hour nonstop flights between Istanbul' in early morning and evening— unfortunately, not the most convenient times to make connections to or from such places as Cappadocia.
Airport buses carry airline passengers from Denizli Bus Terminal, and sometimes from Pamukkale and Karahayıt, to Denizli Çardak Airport for each flight, charging TL13 for the ride. There are only three buses daily to the airport, and three buses returning, timed to the Turkish Airlines and Pegasus Air flights.
Minibuses shuttle between Peron (Gate) 76 on the lower level (beneath the intercity bus gates) of the Denizli Otogar, and Laodicea, Pamukkale and Karahayıt every 15 to 20 minutes all day long. More...
Here's how long it takes to bus or drive to other Turkish cities. More...
—by Tom Brosnahan